Heterogeneous seeding of HET-s(218-289) and the mutability of prion structures.

Abstract excerpt

One fundamental property of prions is the formation of strains-prions that have distinct biological effects, despite a common amino acid sequence. The strain phenomenon is thought to be caused by the formation of different molecular structures, each encoding for a particular biological activity. While the precise mechanism of the formation of strains is unknown, they tend to arise following environmental changes,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Nuclear Magnetic Resonance, Biomolecular
• Share to Prions