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Article

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

The Journal of clinical investigation - 1 Nov 1999

Peakman M, Stevens E J, Lohmann T, Narendran P, Dromey J, Alexander A, Tomlinson A J, Trucco M, Gorga J C, Chicz R M

Abstract excerpt

During immune responses, antigen-presenting cells (APCs) process antigens and present peptide epitopes complexed with human leukocyte antigen (HLA) molecules. CD4 cells recognize these naturally processed and presented epitopes (NPPEs) bound to HLA class II molecules. Epitope identification is important for developing diagnostic and therapeutic tools for immune-mediated diseases and providing insight into their...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10562307
DOI: 10.1172/JCI7936
PMCID: PMC409844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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