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Article

Misfolded CuZnSOD and amyotrophic lateral sclerosis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2003

Valentine Joan Selverstone, Hart P John

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of motor neurons. The inherited form of the disease, familial ALS, represents 5-10% of the total cases, and the best documented of these are due to lesions in SOD1, the gene encoding copper-zinc superoxide dismutase (CuZnSOD). The mechanism by which mutations in SOD1 cause familial ALS is currently unknown. Two hypotheses have dominated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12655070
DOI: 10.1073/pnas.0730423100
PMCID: PMC152971

Genes

SOD1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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