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A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative Stress.

Cell chemical biology - 19 Jul 2018

Trist Benjamin Guy, Hare Dominic James, Double Kay Lorraine

Abstract excerpt

Shared molecular pathologies between distinct neurodegenerative disorders offer unique opportunities to identify common mechanisms of neuron death, and apply lessons learned from one disease to another. Neurotoxic superoxide dismutase 1 (SOD1) proteinopathy in SOD1-associated familial amyotrophic lateral sclerosis (fALS) is recapitulated in idiopathic Parkinson disease (PD), suggesting that these two...

Topics

Animals
Homeostasis
Humans
Metals
Movement Disorders
Mutation
Oxidative Stress
Superoxide Dismutase-1

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29861271
DOI: 10.1016/j.chembiol.2018.05.004

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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