Article
Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene.
Current neurology and neuroscience reports - 1 Jan 2006
Andersen Peter M
Abstract excerpt
This review highlights recent epidemiologic, clinical-genetic, and neurochemical advances in our understanding of sporadic amyotrophic lateral sclerosis (ALS) and their relationships to familial ALS caused by superoxide dismutase (SOD1) gene mutations. It is of fundamental importance to recognize that ALS is a biologically heterogeneous syndrome in which genetics, environment, and aging are inter-related. The...
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