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Article

The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization.

PloS one - 1 Jan 2015

He Qiuxia, Liu Kechun, Tian Zhenjun, Du Shao Jun

Abstract excerpt

Heat shock protein 90α plays a key role in myosin folding and thick filament assembly in muscle cells. To assess the structure and function of Hsp90α and its potential regulation by post-translational modification, we developed a combined knockdown and rescue assay in zebrafish embryos to systematically analyze the effects of various mutations on Hsp90α function in myosin thick filament organization. DNA...

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Identifiers

PMID: 26562659
DOI: 10.1371/journal.pone.0142573
PMCID: PMC4642942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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