Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.

doi:10.1016/0092-8674(90)90723-r

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Article

Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly.

Cell - 12 Jan 1990

Bejsovec A, Anderson P

Abstract excerpt

We have determined the positions and sequences of 31 dominant mutations affecting a C. elegans muscle myosin heavy chain gene. These mutations alter thick filament structure in heterozygotes by interfering with the ability of wild-type myosin to assemble into stable thick filaments. These assembly-disruptive mutations are missense alleles affecting the globular head of myosin. The most strongly dominant alleles...

Topics

Actin Cytoskeleton
Actins
Adenosine Triphosphate
Alleles
Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Caenorhabditis
Codon
Cytoskeleton
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Molecular Sequence Data

Muscles

Mutation

Myosin Subfragments

Myosins

Source

Open in PubMed

Identifiers

PMID: 2136805
DOI: 10.1016/0092-8674(90)90723-r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2136805-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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