Article
Hsp90 selectively modulates phenotype in vertebrate development.
PLoS genetics - 30 Mar 2007
Yeyati Patricia L, Bancewicz Ruth M, Maule John, van Heyningen Veronica
Abstract excerpt
Compromised heat shock protein 90 (Hsp90) function reveals cryptic phenotypes in flies and plants. These observations were interpreted to suggest that this molecular stress-response chaperone has a capacity to buffer underlying genetic variation. Conversely, the protective role of Hsp90 could account for the variable penetrance or severity of some heritable developmental malformations in vertebrates. Using...
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