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Article

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

12 Nov 2015

Abstract excerpt

There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the mechanisms through which they mediate their pathogenic activity during malaria infection remain poorly understood. Utilizing intravital two-photon microscopy combined with detailed ex vivo flow...

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PMID: 26562533
DOI: 10.1371/journal.ppat.1005210

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