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Article

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2012

Villegas-Mendez Ana, Greig Rachel, Shaw Tovah N, de Souza J Brian, Gwyer Findlay Emily, Stumhofer Jason S, Hafalla Julius C R, Blount Daniel G, Hunter Christopher A, Riley Eleanor M, Couper Kevin N

Abstract excerpt

It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P. berghei ANKA infection have not been investigated, and it is not known whether IFN-γ production by a single cell type in isolation can induce cerebral pathology. In this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22723523
DOI: 10.4049/jimmunol.1200688
PMCID: PMC3393641

Genes

CXCL10
CXCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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