Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absolute Quantification of Endogenous Ras Isoform Abundance.

PloS one - 1 Jan 2015

Mageean Craig J, Griffiths John R, Smith Duncan L, Clague Michael J, Prior Ian A

Abstract excerpt

Ras proteins are important signalling hubs situated near the top of networks controlling cell proliferation, differentiation and survival. Three almost identical isoforms, HRAS, KRAS and NRAS, are ubiquitously expressed yet have differing biological and oncogenic properties. In order to help understand the relative biological contributions of each isoform we have optimised a quantitative proteomics method for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Proteomics
Share to Amino Acids
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to GTP Phosphohydrolases

Share to Mass Spectrometry

Share to Protein Isoforms

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 26560143
DOI: 10.1371/journal.pone.0142674
PMCID: PMC4641634

Genes

KRAS
HRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absolute Quantification of Endogenous Ras Isoform Abundance.PMID 26560143Read ↗

Ras protein abundance correlates with Ras isoform mutation patterns in cancer.Semantic proximity Read ↗

Cellular responses to oncogenic Ras signallingSemantic proximity Read ↗

Profiling the kinome in oncogenic RAS mutant cellsSemantic proximity Read ↗

A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions.Semantic proximity Read ↗

The Frequency of Ras Mutations in Cancer.Semantic proximity Read ↗

Isoform-specific Ras expression and signallingSemantic proximity Read ↗

The role of wild type RAS isoforms in cancer.Semantic proximity Read ↗

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS MutationsSemantic proximity Read ↗

Detection and Quantitation of Endogenous Membrane-Bound RAS Proteins and KRAS Mutants in Cancer Cell Lines Using 1D-SDS-PAGE LC-MS2.Semantic proximity Read ↗

Decoding RAS isoform and codon-specific signalling.Semantic proximity Read ↗

Splice variants of RAS-translational significance.Semantic proximity Read ↗

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.