Article
GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation.
The Journal of allergy and clinical immunology - 1 Mar 2016
Naessens Thomas, Schepens Bert, Smet Muriel, Pollard Charlotte, Van Hoecke Lien, De Beuckelaer Ans, Willart Monique, Lambrecht Bart, De Koker Stefaan, Saelens Xavier, Grooten Johan
Abstract excerpt
BACKGROUND: Human respiratory syncytial virus (RSV) is a frequent cause of asthma exacerbations, yet the susceptibility of asthmatic patients to RSV is poorly understood. OBJECTIVE: We sought to address the contribution of resident alveolar macrophages (rAMs) to susceptibility to RSV infection in mice that recovered from allergic airway eosinophilia. METHODS: Mice were infected with RSV virus after clearance of...
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