Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma.

eLife - 18 Jan 2017

Arikkatt Jaisy, Ullah Md Ashik, Short Kirsty Renfree, Zhang Vivan, Gan Wan Jun, Loh Zhixuan, Werder Rhiannon B, Simpson Jennifer, Sly Peter D, Mazzone Stuart B, Spann Kirsten M, Ferreira Manuel Ar, Upham John W, Sukkar Maria B, Phipps Simon

Abstract excerpt

Asthma is a chronic inflammatory disease. Although many patients with asthma develop type-2 dominated eosinophilic inflammation, a number of individuals develop paucigranulocytic asthma, which occurs in the absence of eosinophilia or neutrophilia. The aetiology of paucigranulocytic asthma is unknown. However, both respiratory syncytial virus (RSV) infection and mutations in the receptor for advanced glycation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to HMGB1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HMGB1 Protein

Share to Receptor for Advanced Glycation End Products

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 28099113
DOI: 10.7554/eLife.21199
PMCID: PMC5243115

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma.PMID 28099113Read ↗

Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice.Semantic proximity Read ↗

Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation.Semantic proximity Read ↗

Animal models of allergic airways disease: where are we and where to next?Semantic proximity Read ↗

Neuregulin-1 protects against respiratory viral induced mortalitySemantic proximity Read ↗

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in miceSemantic proximity Read ↗

Advances in the Relationship between Respiratory Viruses and AsthmaSemantic proximity Read ↗

Aerosolized TLR Agonists Suppress Acute Sendai Virus Lung Infection and Chronic Airway Disease in MiceSemantic proximity Read ↗

Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-InfectionsSemantic proximity Read ↗

Long-term alterations in lung epithelial cells after EL-RSV infection exacerbate allergic responses through IL-1β-induced pathwaysSemantic proximity Read ↗

Molecular and cellular mechanisms in the viral exacerbation of asthma.Semantic proximity Read ↗

Respiratory syncytial virus bronchiolitis and asthma - insights from recent studies and implications for therapy.Semantic proximity Read ↗

Early life RSV infection as a preventable risk factor for asthmaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.