Article
Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity.
The American journal of pathology - 1 Jul 2012
Naessens Thomas, Vander Beken Seppe, Bogaert Pieter, Van Rooijen Nico, Lienenklaus Stefan, Weiss Siegfried, De Koker Stefaan, Grooten Johan
Abstract excerpt
Resident alveolar macrophages (rAMs) residing in the bronchoalveolar lumen of the airways play an important role in limiting excessive inflammatory responses in the respiratory tract. High phagocytic activity along with hyporesponsiveness to inflammatory insults and lack of autonomous IFN-β production are crucial assets in this regulatory function. Using a mouse model of asthma, we analyzed the fate of rAMs both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.