Article
Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality.
Oncotarget - 15 Dec 2015
Bárcena Paloma, Jara-Acevedo María, Tabernero María Dolores, López Antonio, Sánchez María Luz, García-Montero Andrés C, Muñoz-García Noemí, Vidriales María Belén, Paiva Artur, Lecrevisse Quentin, Lima Margarida, Langerak Anton W, Böttcher Sebastian, van Dongen Jacques J M, Orfao Alberto, Almeida Julia
Abstract excerpt
Currently, the lack of a universal and specific marker of clonality hampers the diagnosis and classification of chronic expansions of natural killer (NK) cells. Here we investigated the utility of flow cytometric detection of aberrant/altered NK-cell phenotypes as a surrogate marker for clonality, in the diagnostic work-up of chronic lymphoproliferative disorders of NK cells (CLPD-NK). For this purpose, a large...
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