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CD45 Isoform Profile Identifies Natural Killer (NK) Subsets with Differential Activity

21 Apr 2016

Abstract excerpt

The leucocyte-specific phosphatase CD45 is present in two main isoforms: the large CD45RA and the short CD45RO. We have recently shown that distinctive expression of these isoforms distinguishes natural killer (NK) populations. For example, co-expression of both isoforms identifies in vivo the anti tumor NK cells in hematological cancer patients. Here we show that low CD45 expression associates with less mature,...

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PMID: 27100180
DOI: 10.1371/journal.pone.0150434

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