Article
Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder.
Translational psychiatry - 10 Nov 2015
Forstner A J, Hofmann A, Maaser A, Sumer S, Khudayberdiev S, Mühleisen T W, Leber M, Schulze T G, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt S H, Reif A, Müller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Sivalingam S, Verhaert A, Schulz H, Czerski P M, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay J D, Wright A, Mitchell P B, Fullerton J M, Schofield P R, Montgomery G W, Medland S E, Gordon S D, Martin N G, Krasnov V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova L I, Tiganov A S, Polonikov A, Khusnutdinova E, Alda M, Cruceanu C, Rouleau G A, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, Cichon S, Schratt G, Nöthen M M
Abstract excerpt
Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, a class of small noncoding RNAs, contribute to basic mechanisms underlying brain development and plasticity, suggesting...
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