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Article

Integrative analysis of transcriptome-wide association study and mRNA expression profile identified risk genes for bipolar disorder.

Neuroscience letters - 14 Sept 2024

Yang Runxu, Wang Rui, Zhao Dongyan, Lian Kun, Shang Binli, Dong Lei, Yang Xuejuan, Dang Xinglun, Sun Duo, Cheng Yuqi

Abstract excerpt

OBJECTIVE: Bipolar disorder (BD) is a debilitating neuropsychiatric disorder, which is associated with genetic variation through "vast but mixed" Genome-Wide Association Studies (GWAS). Transcriptome-Wide Association Study (TWAS) is more effective in explaining genetic factors that influence complex diseases and can help identifying risk genes more reliably. So, this study aims to identify potential BD risk genes...

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PMID: 39151574
DOI: 10.1016/j.neulet.2024.137935

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