Article
Genetic and functional analyses implicate microRNA 499A in bipolar disorder development.
Translational psychiatry - 7 Oct 2022
Tielke Aileen, Martins Helena, Pelzl Michael A, Maaser-Hecker Anna, David Friederike S, Reinbold Céline S, Streit Fabian, Sirignano Lea, Schwarz Markus, Vedder Helmut, Kammerer-Ciernioch Jutta, Albus Margot, Borrmann-Hassenbach Margitta, Hautzinger Martin, Hünten Karola, Degenhardt Franziska, Fischer Sascha B, Beins Eva C, Herms Stefan, Hoffmann Per, Schulze Thomas G, Witt Stephanie H, Rietschel Marcella, Cichon Sven, Nöthen Markus M, Schratt Gerhard, Forstner Andreas J
Abstract excerpt
Bipolar disorder (BD) is a complex mood disorder with a strong genetic component. Recent studies suggest that microRNAs contribute to psychiatric disorder development. In BD, specific candidate microRNAs have been implicated, in particular miR-137, miR-499a, miR-708, miR-1908 and miR-2113. The aim of the present study was to determine the contribution of these five microRNAs to BD development. For this purpose,...
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