Article

Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs its Signaling Pathways in Liver and Adipose Tissue in Mice

2021-03-05

Abstract excerpt

Spinal cord injury (SCI) results in dysregulation of carbohydrate and lipid metabolism; the underlying cellular and physiological mechanisms remain unclear. Fibroblast growth factor 21 (FGF21) is a circulating protein primarily secreted by the liver that lowers blood glucose levels, corrects abnormal lipid profiles, and mitigates non-alcoholic fatty liver disease. FGF21 acts via activating FGF receptor 1 and ß-klo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98a52314-1db4-52c2-9805-1468564d91fb
DOI: 10.1101/2021.03.04.433932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs its Signaling Pathways in Liver and Adipose Tissue in MiceDOI 10.1101/2021.03.04.433932Read

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.Semantic proximity Read

Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21.Semantic proximity Read

The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic targetSemantic proximity Read

Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.Semantic proximity Read

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoidsSemantic proximity Read

Fibroblast growth factor 21: update on genetics and molecular biology.Semantic proximity Read

FGF21 reflects a responsive adipose tissue-liver axis in both cardiometabolic burden and following metabolic surgerySemantic proximity Read

Reversion of metabolic dysfunction-associated steatohepatitis by skeletal muscle-directed FGF21 gene therapySemantic proximity Read

Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice.Semantic proximity Read

Ketogenic diet-mediated steroid metabolism reprogramming improves the immune microenvironment and myelin growth of spinal cord injury rats through gene analysis and co-expression network analysisSemantic proximity Read

miR-21 blocks obesity in mice: a potential therapy for humansSemantic proximity Read

Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.Semantic proximity Read