Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015

Au Hilda H, Cornilescu Gabriel, Mouzakis Kathryn D, Ren Qian, Burke Jordan E, Lee Seonghoon, Butcher Samuel E, Jan Eric

Abstract excerpt

The dicistrovirus intergenic region internal ribosome entry site (IRES) adopts a triple-pseudoknotted RNA structure and occupies the core ribosomal E, P, and A sites to directly recruit the ribosome and initiate translation at a non-AUG codon. A subset of dicistrovirus IRESs directs translation in the 0 and +1 frames to produce the viral structural proteins and a +1 overlapping open reading frame called ORFx,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Magnetic Resonance Spectroscopy
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Termination Factors

Share to Protein Biosynthesis

Share to Ribosomes

Share to RNA, Transfer

Share to Scattering, Small Angle

Share to X-Ray Diffraction

Source

Open in PubMed Open full text

Identifiers

PMID: 26554019
DOI: 10.1073/pnas.1512088112
PMCID: PMC4664324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection.PMID 26554019Read ↗

Structural determinants of an internal ribosome entry site that direct translational reading frame selection.Semantic proximity Read ↗

Functional Insights into the Adjacent Stem-Loop in Honey Bee Dicistroviruses That Promotes Internal Ribosome Entry Site-Mediated Translation and Viral InfectionSemantic proximity Read ↗

The Hinge Region of the Israeli Acute Paralysis Virus Internal Ribosome Entry Site Directs Ribosomal Positioning, Translational Activity, and Virus Infection.Semantic proximity Read ↗

Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA–like structural element in the ribosomal decoding centerSemantic proximity Read ↗

Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.Semantic proximity Read ↗

Initiation of translation on nedicistrovirus and related intergenic region IRESs by their factor-independent binding to the P site of 80S ribosomesSemantic proximity Read ↗

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in TheilovirusSemantic proximity Read ↗

Naturally occurring dicistronic cricket paralysis virus RNA is regulated by two internal ribosome entry sites.Semantic proximity Read ↗

Conserved element of the dicistrovirus IGR IRES that mimics an E-site tRNA/ribosome interaction mediates multiple functions.Semantic proximity Read ↗

Negative charge in the RACK1 loop broadens the translational capacity of the human ribosomeSemantic proximity Read ↗

Mechanistic role of structurally dynamic regions in Dicistroviridae IGR IRESs.Semantic proximity Read ↗

Molecular analysis of the factorless internal ribosome entry site in Cricket Paralysis virus infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.