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Article

Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4).

Biochimica et biophysica acta. General subjects - 1 Mar 2021

Miura Kazuki, Suzuki Takehiro, Sun Hongkai, Takada Haruka, Ishizawa Yudai, Mizuta Hayato, Dohmae Naoshi, Simizu Siro

Abstract excerpt

BACKGROUND: C-mannosylation is a unique type of glycosylation. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is a multidomain extracellular metalloproteinase that contains several potential C-mannosylation sites. Although some ADAMTS family proteins have been reported to be C-mannosylated proteins, whether C-mannosylation affects the activation and protease activity of these proteins...

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Identifiers

PMID: 33358865
DOI: 10.1016/j.bbagen.2020.129833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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