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Article

Structural insights into the catalytic mechanism of cyclophilin A.

Nature structural biology - 1 Jun 2003

Howard Bruce R, Vajdos Felix F, Li Su, Sundquist Wesley I, Hill Christopher P

Abstract excerpt

Cyclophilins constitute a ubiquitous protein family whose functions include protein folding, transport and signaling. They possess both sequence-specific binding and proline cis-trans isomerase activities, as exemplified by the interaction between cyclophilin A (CypA) and the HIV-1 CA protein. Here, we report crystal structures of CypA in complex with HIV-1 CA protein variants that bind preferentially with the...

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PMID: 12730686
DOI: 10.1038/nsb927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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