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Article

HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities.

The Journal of biological chemistry - 14 Feb 2003

Strong Roland K, Holmes Margaret A, Li Pingwei, Braun Laura, Lee Ni, Geraghty Daniel E

Abstract excerpt

Previous studies of HLA-E allelic polymorphism have indicated that balancing selection may be acting to maintain two major alleles in most populations, indicating that a functional difference may exist between the alleles. The alleles differ at only one amino acid position, where an arginine at position 107 in HLA-E*0101 (E(R)) is replaced by a glycine in HLA-E*0103 (E(G)). To investigate possible functional...

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PMID: 12411439
DOI: 10.1074/jbc.M208268200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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