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Article

Structural dynamics and thermostabilization of neurotensin receptor 1.

The journal of physical chemistry. B - 16 Apr 2015

Lee Sangbae, Bhattacharya Supriyo, Tate Christopher G, Grisshammer Reinhard, Vaidehi Nagarajan

Abstract excerpt

The neurotensin receptor NTSR1 binds the peptide agonist neurotensin (NTS) and signals preferentially via the Gq protein. Recently, Grisshammer and co-workers reported the crystal structure of a thermostable mutant NTSR1-GW5 with NTS bound. Understanding how the mutations thermostabilize the structure would allow efficient design of thermostable mutant GPCRs for protein purification, and subsequent biophysical...

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Identifiers

PMID: 25807267
DOI: 10.1021/jp510735f
PMCID: PMC4564841

Genes

NTSR1
NTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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