Article
The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice.
Tuberculosis (Edinburgh, Scotland) - 1 Nov 2006
Gordhan Bhavna G, Smith Debbie A, Kana Bavesh D, Bancroft Gregory, Mizrahi Valerie
Abstract excerpt
Mycobacterium tuberculosis genes Rv2557 and Rv2558 have no known function. However, proteome, transcriptome and in situ hybridization studies have shown that these genes are significantly upregulated under carbon-starved conditions and in human granulomas, suggesting that they may play a role in persistence. Single and double deletion mutants of M. tuberculosis H37Rv in Rv2557 and/or Rv2558 were generated to...
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