Article
Sar1 assembly regulates membrane constriction and ER export.
The Journal of cell biology - 12 Jul 2010
Long Kimberly R, Yamamoto Yasunori, Baker Adam L, Watkins Simon C, Coyne Carolyn B, Conway James F, Aridor Meir
Abstract excerpt
The guanosine triphosphatase Sar1 controls the assembly and fission of COPII vesicles. Sar1 utilizes an amphipathic N-terminal helix as a wedge that inserts into outer membrane leaflets to induce vesicle neck constriction and control fission. We hypothesize that Sar1 organizes on membranes to con...
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