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Article

Sar1, a Novel Regulator of ER-Mitochondrial Contact Sites.

PloS one - 1 Jan 2016

Ackema Karin B, Prescianotto-Baschong Cristina, Hench Jürgen, Wang Shyi Chyi, Chia Zhi Hui, Mergentaler Heidi, Bard Fredéric, Frank Stephan, Spang Anne

Abstract excerpt

Endoplasmic reticulum (ER)-mitochondrial contact sites play a pivotal role in exchange of lipids and ions between the two organelles. How size and function of these contact sites are regulated remains elusive. Here we report a previously unanticipated, but conserved role of the small GTPase Sar1 in the regulation of ER-mitochondrial contact site size. Activated Sar1 introduces membrane curvature through its...

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Identifiers

PMID: 27101143
DOI: 10.1371/journal.pone.0154280
PMCID: PMC4839682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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