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Article

Targeted exome sequencing profiles genetic alterations in leiomyosarcoma.

Genes, chromosomes & cancer - 1 Feb 2016

Agaram Narasimhan P, Zhang Lei, LeLoarer Francois, Silk Tarik, Sung Yun-Shao, Scott Sasinya N, Kuk Deborah, Qin Li-Xuan, Berger Michael F, Antonescu Cristina R, Singer Samuel

Abstract excerpt

Leiomyosarcoma (LMS) belongs to the class of genetically complex sarcomas and shows numerous, often non-recurrent chromosomal imbalances and aberrations. We investigated a group of LMS using NGS platform to identify recurrent genetic abnormalities and possible therapeutic targets. Targeted exome sequencing of 230 cancer-associated genes was performed on 35 primary soft tissue and visceral (extra-uterine) LMS....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26541895
DOI: 10.1002/gcc.22318
PMCID: PMC4715662

Genes

MYOCD
PTEN
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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