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Article

Targeted exome sequencing profiles genetic alterations in leiomyosarcoma.

Genes, chromosomes & cancer - 1 Feb 2016

Agaram Narasimhan P, Zhang Lei, LeLoarer Francois, Silk Tarik, Sung Yun-Shao, Scott Sasinya N, Kuk Deborah, Qin Li-Xuan, Berger Michael F, Antonescu Cristina R, Singer Samuel

Abstract excerpt

Leiomyosarcoma (LMS) belongs to the class of genetically complex sarcomas and shows numerous, often non-recurrent chromosomal imbalances and aberrations. We investigated a group of LMS using NGS platform to identify recurrent genetic abnormalities and possible therapeutic targets. Targeted exome sequencing of 230 cancer-associated genes was performed on 35 primary soft tissue and visceral (extra-uterine) LMS....

Topics

Adult
Aged
Aged, 80 and over
Exome
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
In Situ Hybridization, Fluorescence
Leiomyosarcoma
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 26541895
DOI: 10.1002/gcc.22318
PMCID: PMC4715662

Genes

MYOCD
PTEN
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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