Article
Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing.
Experimental and molecular pathology - 1 Feb 2017
Lee Paul J, Yoo Naomi S, Hagemann Ian S, Pfeifer John D, Cottrell Catherine E, Abel Haley J, Duncavage Eric J
Abstract excerpt
Recurrent genomic mutations in uterine and non-uterine leiomyosarcomas have not been well established. Using a next generation sequencing (NGS) panel of common cancer-associated genes, 25 leiomyosarcomas arising from multiple sites were examined to explore genetic alterations, including single nucleotide variants (SNV), small insertions/deletions (indels), and copy number alterations (CNA). Sequencing showed 86...
Topics
- Adolescent
- Adult
- Aged
- Ataxia Telangiectasia Mutated Proteins
- DNA Copy Number Variations
- DNA Helicases
- ErbB Receptors
- Female
- Genetic Predisposition to Disease
- High-Throughput Nucleotide Sequencing