Genetic aberrations in soft tissue leiomyosarcoma.

doi:10.1016/j.canlet.2008.06.013

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Article

Genetic aberrations in soft tissue leiomyosarcoma.

Cancer letters - 8 Mar 2009

Yang Jilong, Du Xiaoling, Chen Kexin, Ylipää Antti, Lazar Alexander J F, Trent Jonathan, Lev Dina, Pollock Raphael, Hao Xishan, Hunt Kelly, Zhang Wei

Abstract excerpt

Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular...

Topics

Chromosome Aberrations
Cytogenetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Karyotyping
Leiomyosarcoma
Loss of Heterozygosity
Medical Oncology
Prognosis
Research Design
Soft Tissue Neoplasms

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Identifiers

PMID: 18649996
DOI: 10.1016/j.canlet.2008.06.013
PMCID: PMC2674272

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