Article
Integrated mutational landscape analysis of uterine leiomyosarcomas.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2021
Choi Jungmin, Manzano Aranzazu, Dong Weilai, Bellone Stefania, Bonazzoli Elena, Zammataro Luca, Yao Xiaotong, Deshpande Aditya, Zaidi Samir, Guglielmi Adele, Gnutti Barbara, Nagarkatti Nupur, Tymon-Rosario Joan R, Harold Justin, Mauricio Dennis, Zeybek Burak, Menderes Gulden, Altwerger Gary, Jeong Kyungjo, Zhao Siming, Buza Natalia, Hui Pei, Ravaggi Antonella, Bignotti Eliana, Romani Chiara, Todeschini Paola, Zanotti Laura, Odicino Franco, Pecorelli Sergio, Ardighieri Laura, Bilguvar Kaya, Quick Charles M, Silasi Dan-Arin, Huang Gloria S, Andikyan Vaagn, Clark Mitchell, Ratner Elena, Azodi Masoud, Imielinski Marcin, Schwartz Peter E, Alexandrov Ludmil B, Lifton Richard P, Schlessinger Joseph, Santin Alessandro D
Abstract excerpt
Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 from The Cancer Genome Atlas (TCGA). Among them, a total of 55 Yale samples including two patient-derived xenografts (PDXs) and 27 TCGA samples have whole-exome sequencing (WES) data; 10 Yale and 27 TCGA samples have RNA-sequencing (RNA-Seq)...
Topics
- Animals
- Antineoplastic Agents
- Female
- Genotype
- Humans
- Leiomyosarcoma