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Article

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

5 Nov 2015

Abstract excerpt

In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become increasingly restricted in their differentiation potential through oligopotent and then unipotent progenitors. We developed a cell-sorting scheme to resolve myeloid (My), erythroid (Er), and megakaryocytic (Mk) fates from single CD34(+) cells and then mapped the...

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PMID: 26541609
DOI: 10.1126/science.aab2116

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