Article
Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development.
Stem cell reports - 8 Apr 2014
Inlay Matthew A, Serwold Thomas, Mosley Adriane, Fathman John W, Dimov Ivan K, Seita Jun, Weissman Irving L
Abstract excerpt
Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability) gradually arise. Whereas self-renewal and engraftability have previously been examined in the embryo, multipotency has not been thoroughly addressed, especially at the...
Topics
- Animals
- Antigens, Surface
- CD11a Antigen
- Cell Differentiation
- Cell Lineage
- Colony-Forming Units Assay
- Embryonic Development
- Female
- Hematopoietic Stem Cells
- Immunophenotyping
- Leukosialin
- Mice
- Multipotent Stem Cells