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Article

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

1 Oct 2018

Abstract excerpt

Abstract Capturing where and how multipotency is lost is crucial to understand how blood formation is controlled. Blood lineage specification is currently thought to occur downstream of multipotent haematopoietic stem cells (HSC). Here we show that, in human, the first lineage restriction events occur within the CD19 − CD34 + CD38 − CD45RA − CD49f + CD90 + (49f + ) HSC compartment to generate myelo-lymphoid...

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PMID: 30291229
DOI: 10.1038/s41467-018-06442-4

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