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Article

Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1.

Protein science : a publication of the Protein Society - 1 Feb 2016

Qureshi Tihami, Peterson Cynthia B

Abstract excerpt

The serine protease inhibitor (serpin), plasminogen activator inhibitor-1 (PAI-1), is an important biomarker for cardiovascular disease and many cancers. It is therefore a desirable target for pharmaceutical intervention. However, to date, no PAI-1 inhibitor has successfully reached clinical trial, indicating the necessity to learn more about the mechanics of the serpin. Although its kinetics of inhibition have...

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Identifiers

PMID: 26540464
DOI: 10.1002/pro.2839
PMCID: PMC4815349

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Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1.PMID 26540464Read ↗

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Structural factors affecting the choice between latency transition and polymerization in inhibitory serpins.Semantic proximity Read ↗

Importance of the amino-acid composition of the shutter region of plasminogen activator inhibitor-1 for its transitions to latent and substrate forms.Semantic proximity Read ↗

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition.Semantic proximity Read ↗

Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.Semantic proximity Read ↗

Conformational studies of plasminogen activator inhibitor type 1 by fluorescence spectroscopy. Analysis of the reactive centre of inhibitory and substrate forms, and of their respective reactive-centre cleaved forms.Semantic proximity Read ↗

Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.Semantic proximity Read ↗

Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands.Semantic proximity Read ↗

Reactive Center Loop Insertion in α-1-Antitrypsin Captured by Accelerated Molecular Dynamics Simulation.Semantic proximity Read ↗

Distal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteases.Semantic proximity Read ↗

Structural bases of the redox-dependent conformational switch in the serpin PAI-2.Semantic proximity Read ↗

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stabilitySemantic proximity Read ↗

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