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Article

Structural factors affecting the choice between latency transition and polymerization in inhibitory serpins.

Protein science : a publication of the Protein Society - 1 May 2007

Yi Ji-Yeun, Im Hana

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) protein family, is unique among the serpins in its conformational lability. This lability allows spontaneous conversion of the active form to a more stable, latent conformation under physiological conditions. In other serpins, polymerization, rather than latency transition, is induced under pathological conditions or...

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Identifiers

PMID: 17400919
DOI: 10.1110/ps.062745807
PMCID: PMC2206651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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