Article

Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability

2022-07-20

Abstract excerpt

<h4>ABSTRACT</h4> Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (SERPIN) superfamily of proteins, is unique among SERPINs for exhibiting a spontaneous conformational change to a latent or inactive state. The functional half-life for this transition at physiologic temperature and pH is ~1-2 h. To better understand the molecular mechanisms underlying this transition, we now re...

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Literature Corpus work: 8c66d11e-654b-5d37-8480-a5fd8fa19b81
DOI: 10.1101/2022.07.19.500671

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