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Article

Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands.

The Journal of biological chemistry - 27 Jun 2008

Li Shih-Hon, Gorlatova Natalia V, Lawrence Daniel A, Schwartz Bradford S

Abstract excerpt

Plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor (serpin) in which the reactive center loop (RCL) spontaneously inserts into a central beta-sheet, beta-sheet A, resulting in inactive inhibitor. Available x-ray crystallographic studies of PAI-1 in an active conformation relied on the use of stabilizing mutations. Recently it has become evident that these structural models do not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18436534
DOI: 10.1074/jbc.M709455200
PMCID: PMC2440609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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