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Article

Reactive Center Loop Insertion in α-1-Antitrypsin Captured by Accelerated Molecular Dynamics Simulation.

Biochemistry - 31 Jan 2017

Andersen Ole Juul, Risør Michael Wulff, Poulsen Emil Christian, Nielsen Niels Chr, Miao Yinglong, Enghild Jan J, Schiøtt Birgit

Abstract excerpt

Protease inhibition by metastable serine protease inhibitors (serpins) is mediated by one of the largest functional intradomain conformational changes known in biology. In this extensive structural rearrangement, protease-serpin complex formation triggers cleavage of the serpin reactive center loop (RCL), its subsequent insertion into central β-sheet A, and covalent trapping of the target protease. In this study,...

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Identifiers

PMID: 27995800
DOI: 10.1021/acs.biochem.6b00839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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