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Article

MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma.

Genetics and molecular research : GMR - 27 Oct 2015

Anders Q S, Stur E, Agostini L P, Garcia F M, Reis R S, Santos J A, Mendes S O, Maia L L, Peterle G T, Stange V, Carvalho M B, Tajara E H, Santos M, Silva-Conforti A M A, Louro I D

Abstract excerpt

The C677T and A1298C polymorphisms in methylene-tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous cell carcinoma (HNSCC) may respond differently to...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26535623
DOI: 10.4238/2015.October.26.6

Genes

MTHFR

Variants

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