Article
Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients.
Neuro-oncology - 1 Nov 2016
Jafari-Khouzani Kourosh, Loebel Franziska, Bogner Wolfgang, Rapalino Otto, Gonzalez Gilberto R, Gerstner Elizabeth, Chi Andrew S, Batchelor Tracy T, Rosen Bruce R, Unkelbach Jan, Shih Helen A, Cahill Daniel P, Andronesi Ovidiu C
Abstract excerpt
BACKGROUND: Gliomas with mutant isocitrate dehydrogenase (IDH) produce high levels of 2-hydroxyglutarate (2HG) that can be quantitatively measured by 3D magnetic resonance spectroscopic imaging (MRSI). Current glioma MRI primarily relies upon fluid-attenuated inversion recovery (FLAIR) hyperintensity for treatment planning, although this lacks specificity for tumor cells. Here, we investigated the relationship...
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