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Engineered mtZFNs for Manipulation of Human Mitochondrial DNA Heteroplasmy.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Gammage Payam A, Van Haute Lindsey, Minczuk Michal

Abstract excerpt

Enrichment of desired mitochondrial DNA (mtDNA) haplotypes, in both experimental systems and the clinic, is an end sought by many. Through use of a designer nuclease platform optimized for delivery to mitochondria-the mitochondrially targeted zinc finger-nuclease (mtZFN)-it is possible to discriminate between mtDNA haplotypes with specificity to the order of a single nucleotide substitution. Site-specific...

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PMID: 26530680
DOI: 10.1007/978-1-4939-3040-1_11

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