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Article

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

Nucleic acids research - 1 Jul 2008

Minczuk Michal, Papworth Monika A, Miller Jeffrey C, Murphy Michael P, Klug Aaron

Abstract excerpt

The selective degradation of mutated mitochondrial DNA (mtDNA) molecules is a potential strategy to re-populate cells with wild-type (wt) mtDNA molecules and thereby alleviate the defective mitochondrial function that underlies mtDNA diseases. Zinc finger nucleases (ZFNs), which are nucleases conjugated to a zinc-finger peptide (ZFP) engineered to bind a specific DNA sequence, could be useful for the selective...

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Identifiers

PMID: 18511461
DOI: 10.1093/nar/gkn313
PMCID: PMC2475635

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Source receipt: pubmed, retrieved 7 Sept 2026.

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