Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manipulation of Murine Mitochondrial DNA Heteroplasmy with mtZFNs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Nash Pavel A, Minczuk Michal

Abstract excerpt

Mouse models of mitochondrial DNA mutations hold promise in the development and optimization of mitochondrial gene therapy technology and for gathering pre-clinical data prior to human trials. Their suitability for this purpose stems from the high similarity of human and murine mitochondrial genomes and the increasing availability of rationally designed AAV vectors capable of selectively transducing murine...

Topics

Join the communities discussing this publication.

DNA, Mitochondrial
Heteroplasmy
Mice
Mitochondria
Mitochondrial Diseases
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36807802
DOI: 10.1007/978-1-0716-2922-2_23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manipulation of Murine Mitochondrial DNA Heteroplasmy with mtZFNs.PMID 36807802Read ↗

Current strategies towards therapeutic manipulation of mtDNA heteroplasmy.Semantic proximity Read ↗

Current progress with mammalian models of mitochondrial DNA disease.Semantic proximity Read ↗

Manipulation of mitochondrial genes and mtDNA heteroplasmy.Semantic proximity Read ↗

Engineered mtZFNs for Manipulation of Human Mitochondrial DNA Heteroplasmy.Semantic proximity Read ↗

Delivery of mtZFNs into Early Mouse Embryos.Semantic proximity Read ↗

Enhanced Manipulation of Human Mitochondrial DNA Heteroplasmy In Vitro Using Tunable mtZFN Technology.Semantic proximity Read ↗

Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases.Semantic proximity Read ↗

Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture.Semantic proximity Read ↗

The use of mitochondria-targeted endonucleases to manipulate mtDNA.Semantic proximity Read ↗

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Semantic proximity Read ↗

Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.Semantic proximity Read ↗

In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.