Article
Functional ET(A)-ET(B) Receptor Cross-talk in Basilar Artery In Situ From ET(B) Receptor Deficient Rats.
Journal of cardiovascular pharmacology - 1 Mar 2016
Yoon SeongHun, Gariepy Cheryl E, Yanagisawa Masashi, Zuccarello Mario, Rapoport Robert M
Abstract excerpt
The role of endothelin (ET)(A)-ET(B) receptor cross-talk in limiting the ET(A) receptor antagonist inhibition of ET-1 constriction is revealed by the partial or complete dependency of the ET(A) receptor antagonist inhibition on functional removal of the ET(B) receptor. Although functional removal of the ET(B) receptor is generally accomplished with ET(B) receptor antagonist, a novel approach using rats containing...
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