Article
Endothelin A receptor is necessary for O(2) constriction but not closure of ductus arteriosus.
The American journal of physiology - 1 Oct 1999
Coceani F, Liu Y, Seidlitz E, Kelsey L, Kuwaki T, Ackerley C, Yanagisawa M
Abstract excerpt
In vitro and in vivo techniques were developed with genetically modified mice to determine whether endothelin-1 (ET-1) functions as an O(2) mediator in closure of the ductus arteriosus (DA) at birth. Wild-type CD-1 and 129/SvEv mice with ET(A) receptor -/-, +/-, and +/+ genotypes were used. Isolated DA from term ET(A) +/+ fetuses contracted to O(2) (5-95%) and a thromboxane A(2) analog (ONO-11113, 0.1 microM)....
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