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Article

Phenotype, intestinal morphology, and survival of homozygous and heterozygous endothelin B receptor--deficient (spotting lethal) rats.

Journal of pediatric surgery - 1 Mar 2000

Dembowski C, Hofmann P, Koch T, Kamrowski-Kruck H, Riedesel H, Krammer H J, Kaup F J, Ehrenreich H

Abstract excerpt

BACKGROUND/PURPOSE: Spotting lethal (sl) rats, a model for Hirschsprung's disease, recently have been found to carry a deletion in the endothelin B (ET(B)) gene, causing functional lack of ET(B) receptors. The ET(B) receptor mediates, together with and in counterbalance to the ET(A) receptor, endothelin actions on vessels, cell proliferation, and migration. The authors investigated the effect of homozygosity...

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PMID: 10726693
DOI: 10.1016/s0022-3468(00)90218-5

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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