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Article

Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2009

Zhang Junlan, Ling Yiqun, Tang Liping, Luo Bao, Pollock David M, Fallon Michael B

Abstract excerpt

Experimental hepatopulmonary syndrome (HPS) after common bile duct ligation (CBDL) in rat is accompanied by increased lung vascular endothelial endothelin B (ETB) receptor expression and increased circulating levels of endothelin-1 (ET-1). The onset of HPS is hypothesized to be triggered by ET-1/ETB receptor activation of endothelial nitric oxide synthase (eNOS)-derived NO production in the pulmonary endothelium....

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Identifiers

PMID: 19196949
DOI: 10.1152/ajpgi.90627.2008
PMCID: PMC2670670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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