Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polycomb repressive complex 2 impedes intestinal cell terminal differentiation

1 Jan 2012

Abstract excerpt

The crypt-villus axis constitutes the functional unit of the small intestine, where mature absorptive cells are confined to the villi, and stem cells and transit amplifying and differentiating cells are restricted to the crypts. The polycomb group (PcG) proteins repress differentiation and promote self-renewal in embryonic stem cells. PcGs prevent transcriptional activity by catalysing epigenetic modifications,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22467857
DOI: 10.1242/jcs.102061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polycomb repressive complex 2 impedes intestinal cell terminal differentiationPMID 22467857Read ↗

Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or NeoplasiaSemantic proximity Read ↗

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.Semantic proximity Read ↗

Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell PlasticitySemantic proximity Read ↗

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem CellsSemantic proximity Read ↗

NSUN2 drives intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signallingSemantic proximity Read ↗

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cellsSemantic proximity Read ↗

Intestinal Epithelial Cell Differentiation Involves Activation of p38 Mitogen-activated Protein Kinase That Regulates the Homeobox Transcription Factor CDX2Semantic proximity Read ↗

BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.Semantic proximity Read ↗

EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/β-catenin signalingSemantic proximity Read ↗

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.Semantic proximity Read ↗

Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.